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Scientist Meriden, CT

Company: Genzyme Therapeutics
Location: Meriden
Posted on: June 15, 2020

Job Description:

The Primary responsibility of the Scientist will be to assist in the development and execution of experiments in all upstream activities through SOPs and documented protocols. Duties will include cell culture maintenance, virus expansion and preparation of seed and cell scale-up for bioreactor experiments. - One of the key primary responsibilities will be to perform limited dilution cloning for the generation of the new cell line, evaluate cell line(s) for their ability to be infected with the Baculovirus. In addition, the scientist will be interacting with other functions to determine the yield and purity of the protein expressed in the new cell line(s). - Secondary responsibilities will be to compile and analyze experimental data including on-line and off-line sources and maintain database.Duties will include but not limited to operation and maintenance of bioreactors through execution of SOPs and protocols, data mining and analysis. - Tertiary responsibilities will be to assist in basic laboratory analytical techniques. Duties will include SDS-PAGE, Western blots, SRID assay, pH meters, etc. The candidate is capable of identifying and troubleshooting the USP operation problems in small-scale bioreactors and participates in the process improvement program. Key Accountabilities: - Responsible for completing paperwork for each task, cleaning procedures, aseptic processing techniques. - Conduct routine preventive maintenance of bioreactors and other upstream equipment as needed. - Maintains laboratory notebook documentation in accordance with PD department rules. - Maintains laboratory inventory and equipment. - Develop new cell lines using the limited dilution cloning strategy, follow the growth characteristics of the new cell, adaptation of the cells in suspension culture and also develop process for screening the new cell line for the growth, infect-ability and protein production. - Develop working virus banks for the expression and production of recombinant proteins - Write experimental plans, protocols and reports - Records process development activities and results in PD notebooks and spreadsheets. - Assist in the execution of all tasks requested by internal and external collaborations/Customers. - Participates in the cleaning and maintenance of the bioreactor room - Assist in updating and maintaining the schedule. BASIC QUALIFICATIONS: - Minimum Master's degree in Biology, Chemistry, Biochemistry, Chemical Engineering, or in a similar field of study AND - Minimum 5 years' experience in cell culture procedures and associated aseptic techniques; process development and process scale-up OR - PhD in Biology, Chemistry, Biochemistry, Chemical Engineering, or in a similar field of study AND - Minimum 2 years' experience in cell culture procedures and associated aseptic techniques; process development and process scale-up PREFERRED QUALIFICATIONS: - Experience in molecular biology techniques and protein chemistry will be a plus. - Hands-on experience with bioreactors and recombinant protein production is strongly desired - General laboratory skills, and also experience in process controls will be highly desirable. - Experiences in the Biotechnology and pharmaceutical industry is a plus OTHER SKILLS / COMPETENCIES: - Able to work effectively in a collaborative team and to prioritize assignments - English fluent, both written and spoken. - Strong verbal and written communication skills - Willing to work changing work schedules and hours as needed Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SP #LI-SP At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Genzyme Therapeutics, Meriden , Scientist Meriden, CT, Other , Meriden, Connecticut

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